You are here: Vanderbilt Biostatistics Wiki>Main Web>Education>HandoutsBioRes>BioMod (revision 16)~~Edit~~~~Attach~~

- Syllabus from a course on Biostatistical Modeling (updated 9Jan03; click here for a pdf file for printing), lecture notes, concepts to master and supplemental notes (6 pages; updated 26Jan99)
- Homework assignments
- Problems with categorizing continuous variables
- Some useful equations for linear regression (26Jan99, PDF, 3 pages)
- Handouts on ordinary least squares regression and regression diagnostics by Jim Patrie (20Mar01, PDF, 73 pages)

- S scripts demonstrating various modeling building blocks.
- Interactive demonstration for a single predictor: linear and quadratic fit, categorization, addition of noise, and power
- Requires running in RStudio as well as the Hmisc package

- Curve fitting for a single predictor: least squares, least sum of absolute deviations, least median squared deviation, loess (requires Hmisc and MASS packages, updated 25Dec12)
- Fitting linear, linear spline, quartic polynomial, unrestricted cubic spline, and restricted cubic spline functions for a single predictor (requires Hmisc and rms packages, 25Dec12); see also here
- Random examples of restricted cubic spline functions with 3 - 7 knots (requires Hmisc package, 25Feb99)
- Miscellaneous examples of splines and effects of changing knots
- Demonstration of loess details by Greg Snow, BYU

- Interactive demonstration for a single predictor: linear and quadratic fit, categorization, addition of noise, and power
- Example of using restricted cubic spline functions to model time-response profiles from serially collected patient data (hormone levels from blood draws every 10 minutes in each subject)
- Cluster bootstrap used to get confidence intervals accounting for intra-subject correlation
- Bootstrap bumping used to get simultaneous confidence bands
- Estimates and bands are for the difference in time-response mean profiles for older vs. younger subjects
- Analyses done using R
`Hmisc`

package function`rm.boot`

- Kevin Quinn's web site on logistic regression and log-linear modeling (has good examples of the S
`glm`

function and some Bayesian methods) - Binary logistic regression example from basic biomedical research showing a fit with and without interaction (Wenger et al, Can J Physiol Pharmacol 62:224, 1984)
- Ordinary Least Squares Regression and Regression Diagnostics (Jim Patrie, 20Mar01, 73 pages)
- Notes of problems in using ratios as dependent variables, from Rich Goldstein (15Jul99)
- Use of the Cox Semiparametric Regression Model for Predicting Costs, Charges, and Length of Stay; FE Harrell and LR Smith;Short Course, Meeting on Methodologic Issues in Health Services and Outcomes Research, 3Dec95)
- REGRESSION MODELING STRATEGIES with Applications to Linear Models, Logistic Regression, and Survival Analysis, Book and Short Courses by FE Harrell.
- MSCI Biostatistics II Course
- R-based site for rank-based linear models by Abebe, Crimin,
McKean, Haas, Vidmar (see Drug Information Journal 35:947-971, 2001). - Doug Bates' presentation Using Open Source Software to Teach Mathematical Statistics, with examples of distribution fitting using maximum likelihood, profile likelihood plotting, and other statistical calculations
- University of Otago's student tutorials on Monte Carlo methods, principal components analysis, the bootstrap, clustering,

-- ColeBeck - 09 Mar 2004

I | Attachment | Action | Size | Date | Who | Comment |
---|---|---|---|---|---|---|

html | biomod.html | manage | 20.6 K | 09 Mar 2004 - 16:03 | ColeBeck | |

biomod.pdf | manage | 98.0 K | 09 Mar 2004 - 16:03 | ColeBeck | ||

html | concepts.html | manage | 3.4 K | 09 Mar 2004 - 16:03 | ColeBeck | |

suppnotes.pdf | manage | 143.0 K | 09 Mar 2004 - 16:03 | ColeBeck | ||

formulas.pdf | manage | 99.8 K | 09 Mar 2004 - 16:04 | ColeBeck | ||

ssc | loess.demo.ssc | manage | 2.4 K | 09 Mar 2004 - 16:05 | ColeBeck | |

ssc | rcspline.examples.ssc | manage | 0.7 K | 09 Mar 2004 - 16:05 | ColeBeck | |

patrie.regression.pdf | manage | 381.3 K | 09 Mar 2004 - 16:06 | ColeBeck | ||

goldstein.ratios.pdf | manage | 109.4 K | 09 Mar 2004 - 16:20 | ColeBeck | ||

hpstat95.pdf | manage | 599.8 K | 09 Mar 2004 - 16:20 | ColeBeck | ||

biostatModHw.pdf | manage | 80.4 K | 10 Mar 2004 - 08:42 | ColeBeck | ||

notes.pdf | manage | 1405.3 K | 02 Jan 2008 - 16:02 | FrankHarrell | Biostatistical Modeling Notes | |

png | vfib.png | manage | 124.1 K | 07 Apr 2008 - 17:41 | FrankHarrell | Binary logistic regression example from Regression Modeling Strategies |

hart3.pdf | manage | 50.6 K | 16 Apr 2008 - 22:18 | FrankHarrell | Example of simultaneous confidence bands for difference in two time-response curves | |

r | catgNoise.r | manage | 4.5 K | 29 May 2011 - 09:33 | FrankHarrell | Interactive demonstration in RStudio: power with categorization and noise |

r | demo.spline.r | manage | 1.9 K | 25 Dec 2012 - 13:25 | FrankHarrell | Interactive demo of spline and polynomial fitting |

r | demo.least.squares.r | manage | 1.0 K | 25 Dec 2012 - 13:42 | FrankHarrell | Demo of linear fits using least squares and robust fits, and loess |

Topic revision: r16 - 12 Feb 2013, LindaStewart

Copyright © 2013-2020 by the contributing authors. All material on this collaboration platform is the property of the contributing authors.

Ideas, requests, problems regarding Vanderbilt Biostatistics Wiki? Send feedback

Ideas, requests, problems regarding Vanderbilt Biostatistics Wiki? Send feedback